Histopathology reveals concealed aortic valve inflammation
Laaksonen, Mona; Kholova, Ivana; Paavonen, Timo; Mennander, Ari (2024-02)
Laaksonen, Mona
Kholova, Ivana
Paavonen, Timo
Mennander, Ari
02 / 2024
41
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202403142854
https://urn.fi/URN:NBN:fi:tuni-202403142854
Kuvaus
Peer reviewed
Tiivistelmä
Background: The extent of aortic valve inflammation in patients undergoing aortic valve replacement (AVR) is unsettled. The significance of aortic valve histopathology in patients undergoing AVR is undetermined. Methods: A total of 145 resected aortic valves of consecutive patients undergoing surgery for a local aortic valve disease with or without ascending aorta were investigated for histopathology. The extent of inflammation and degeneration were investigated. Unadjusted survival was evaluated by Kaplan–Meier analysis. Median follow-up was 2.7 years (interquartile range 1.5–3.9). Results: Mean patient age was 69 (SD 11) years. Though endocarditis was apparent in only six patients preoperatively, severe aortic valve inflammation was diagnosed histologically in 32 patients of whom 12 patients had acute, subacute or chronic endocarditis. Despite complete aortic valve resection, survival was decreased in patients with severe aortic valve inflammation as opposed to those without (log rank, P = 0.044), even after exclusion of patients with endocarditis, emergency and aortic surgery. Conclusions: Aortic valve tissue analysis reveals severe inflammation that may require postoperative treatment. The association of severe but local aortic valve inflammation with patient outcome after aortic valve surgery merits further investigation.
Kokoelmat
- TUNICRIS-julkaisut [17063]