Increased HLA class II risk is associated with a more aggressive presentation of clinical type 1 diabetes
Kieleväinen, Vilma; Turtinen, Maaret; Luopajärvi, Kristiina; Härkönen, Taina; Ilonen, Jorma; Knip, Mikael; Finnish Pediatric Diabetes Register (2022)
Kieleväinen, Vilma
Turtinen, Maaret
Luopajärvi, Kristiina
Härkönen, Taina
Ilonen, Jorma
Knip, Mikael
Finnish Pediatric Diabetes Register
2022
Acta Paediatrica, International Journal of Paediatrics
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202301201590
https://urn.fi/URN:NBN:fi:tuni-202301201590
Kuvaus
Peer reviewed
Tiivistelmä
Aim: To determine the association of HLA class II risk with the demographic and clinical characteristics of type 1 diabetes at diagnosis. Methods: We conducted a register-based retrospective cohort study of 4993 Finnish children (2169 girls) – diagnosed with type 1 diabetes under the age of 15 years in 2003–2016. The participants were divided into six risk groups based on their HLA DR/DQ genotype. Demographic characteristics, family history of type 1 diabetes and metabolic markers at the time of diagnosis were compared between the groups. Results: In total, 4056/4993 children (81.2%) carried an HLA genotype associated with an increased risk of type 1 diabetes (risk groups 3–5), whereas 937/4993 children (18.8%) carried a HLA genotype conferring no or decreased disease risk. Children with higher HLA risk were younger at diagnosis (p < 0.001) and had a shorter duration of classical symptoms before diagnosis (p = 0.016). Subjects in the high-risk group were more likely to have a family member affected by type 1 diabetes when compared to those in the neutral risk group (11.5% vs. 8.8%, p = 0.05). Conclusion: Children with stronger HLA disease susceptibility are younger at their disease manifestation and have a shorter period of symptoms before diagnosis, suggesting that the HLA class II genes are associated with a more aggressive disease presentation.
Kokoelmat
- TUNICRIS-julkaisut [17001]