Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles
International Headache Genetics Consortium; HUNT All-in Headache; Danish Blood Donor Study Genomic Cohort; Hautakangas, Heidi; Winsvold, Bendik S.; Ruotsalainen, Sanni E.; Bjornsdottir, Gyda; Harder, Aster V.E.; Kogelman, Lisette J.A.; Thomas, Laurent F.; Noordam, Raymond; Benner, Christian; Gormley, Padhraig; Artto, Ville; Banasik, Karina; Bjornsdottir, Anna; Boomsma, Dorret I.; Brumpton, Ben M.; Burgdorf, Kristoffer Sølvsten; Buring, Julie E.; Chalmer, Mona Ameri; de Boer, Irene; Dichgans, Martin; Erikstrup, Christian; Färkkilä, Markus; Garbrielsen, Maiken Elvestad; Ghanbari, Mohsen; Hagen, Knut; Häppölä, Paavo; Hottenga, Jouke Jan; Hrafnsdottir, Maria G.; Hveem, Kristian; Johnsen, Marianne Bakke; Kähönen, Mika; Kristoffersen, Espen S.; Kurth, Tobias; Lehtimäki, Terho; Lighart, Lannie; Magnusson, Sigurdur H.; Malik, Rainer; Pedersen, Ole Birger; Pelzer, Nadine; Penninx, Brenda W.J.H.; Ran, Caroline; Ridker, Paul M.; Rosendaal, Frits R.; Sigurdardottir, Gudrun R.; Skogholt, Anne Heidi; Sveinsson, Olafur A.; Thorgeirsson, Thorgeir E.; Ullum, Henrik; Vijfhuizen, Lisanne S.; Hansen, Thomas Folkmann (2022-02)
International Headache Genetics Consortium
HUNT All-in Headache
Danish Blood Donor Study Genomic Cohort
Hautakangas, Heidi
Winsvold, Bendik S.
Ruotsalainen, Sanni E.
Bjornsdottir, Gyda
Harder, Aster V.E.
Kogelman, Lisette J.A.
Thomas, Laurent F.
Noordam, Raymond
Benner, Christian
Gormley, Padhraig
Artto, Ville
Banasik, Karina
Bjornsdottir, Anna
Boomsma, Dorret I.
Brumpton, Ben M.
Burgdorf, Kristoffer Sølvsten
Buring, Julie E.
Chalmer, Mona Ameri
de Boer, Irene
Dichgans, Martin
Erikstrup, Christian
Färkkilä, Markus
Garbrielsen, Maiken Elvestad
Ghanbari, Mohsen
Hagen, Knut
Häppölä, Paavo
Hottenga, Jouke Jan
Hrafnsdottir, Maria G.
Hveem, Kristian
Johnsen, Marianne Bakke
Kähönen, Mika
Kristoffersen, Espen S.
Kurth, Tobias
Lehtimäki, Terho
Lighart, Lannie
Magnusson, Sigurdur H.
Malik, Rainer
Pedersen, Ole Birger
Pelzer, Nadine
Penninx, Brenda W.J.H.
Ran, Caroline
Ridker, Paul M.
Rosendaal, Frits R.
Sigurdardottir, Gudrun R.
Skogholt, Anne Heidi
Sveinsson, Olafur A.
Thorgeirsson, Thorgeir E.
Ullum, Henrik
Vijfhuizen, Lisanne S.
Hansen, Thomas Folkmann
02 / 2022
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202205195094
https://urn.fi/URN:NBN:fi:tuni-202205195094
Kuvaus
Peer reviewed
Tiivistelmä
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and migraine without aura. Stratification of the risk loci using 29,679 cases with subtype information indicated three risk variants that seem specific for migraine with aura (in HMOX2, CACNA1A and MPPED2), two that seem specific for migraine without aura (near SPINK2 and near FECH) and nine that increase susceptibility for migraine regardless of subtype. The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Overall, genomic annotations among migraine-associated variants were enriched in both vascular and central nervous system tissue/cell types, supporting unequivocally that neurovascular mechanisms underlie migraine pathophysiology.
Kokoelmat
- TUNICRIS-julkaisut [17001]