Characteristics of preeclampsia in donor cell gestations
Ervaala, Attina; Laivuori, Hannele; Gissler, Mika; Kere, Juha; Kivinen, Katja; Pouta, Anneli; Kajantie, Eero; Heinonen, Seppo; Wedenoja, Satu (2022-03)
Ervaala, Attina
Laivuori, Hannele
Gissler, Mika
Kere, Juha
Kivinen, Katja
Pouta, Anneli
Kajantie, Eero
Heinonen, Seppo
Wedenoja, Satu
03 / 2022
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202201041071
https://urn.fi/URN:NBN:fi:tuni-202201041071
Kuvaus
Peer reviewed
Tiivistelmä
Pregnancies conceived through donor oocytes or sperm show increased risk for preeclampsia. We studied this issue in a preeclampsia case-control cohort (n = 2778), and found overrepresentation of donor cell gestations among women with preeclampsia (14/1627, 0.86%; OR 1.81; 95% CI: 1.07-3.08; P = 0.025) compared to the population data. Moreover, we observed excess of male births from donor cell pregnancies (male-to-female ratio 2.5 vs. 0.97; OR 2.57; 95% CI 1.02-6.36; P = 0.043). Maternal age (36.7 vs. 30.2; P < 0.0001) and preterm deliveries (64% vs. 38%; P = 0.046) distinguished donor cell gestations from other pregnancies with preeclampsia. These results support foreign fetal antigens as modulators of preeclampsia.
Kokoelmat
- TUNICRIS-julkaisut [17001]