Crosstalk between long noncoding RNA and microRNA in Cancer

Rahul Bhattacharjee; Neeraj Prabhakar; Lamha Kumar; Arkadyuti Bhattacharjee; Sulagna Kar; Sumira Malik; Dhruv Kumar; Janne Ruokolainen; Arvind Negi; Niraj Kumar Jha; Kavindra Kumar Kesari

doi:10.1007/s13402-023-00806-9

Crosstalk between long noncoding RNA and microRNA in Cancer

Rahul Bhattacharjee, Neeraj Prabhakar, Lamha Kumar, Arkadyuti Bhattacharjee, Sulagna Kar, Sumira Malik, Dhruv Kumar, Janne Ruokolainen, Arvind Negi, Niraj Kumar Jha, Kavindra Kumar Kesari

Research output: Contribution to journal › Review Article or Literature Review › peer-review

12 Citations (Scopus)

3 Downloads (Pure)

Abstract

miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management.

Original language	English
Pages (from-to)	885-908
Number of pages	24
Journal	Cellular Oncology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1007/s13402-023-00806-9
Publication status	Published - Aug 2023
MoE publication type	A2 Review article in a scientific journal

Keywords

Humans
MicroRNAs/genetics
RNA, Long Noncoding/genetics
Neoplasms/genetics
Neovascularization, Pathologic/genetics
Epithelial-Mesenchymal Transition/genetics
Gene Expression Regulation, Neoplastic

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10.1007/s13402-023-00806-9

s13402-023-00806-9Final published version, 3.19 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe202402065872

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title = "Crosstalk between long noncoding RNA and microRNA in Cancer",

abstract = "miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management.",

keywords = "Humans, MicroRNAs/genetics, RNA, Long Noncoding/genetics, Neoplasms/genetics, Neovascularization, Pathologic/genetics, Epithelial-Mesenchymal Transition/genetics, Gene Expression Regulation, Neoplastic",

author = "Rahul Bhattacharjee and Neeraj Prabhakar and Lamha Kumar and Arkadyuti Bhattacharjee and Sulagna Kar and Sumira Malik and Dhruv Kumar and Janne Ruokolainen and Arvind Negi and Jha, {Niraj Kumar} and Kesari, {Kavindra Kumar}",

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year = "2023",

month = aug,

doi = "10.1007/s13402-023-00806-9",

language = "English",

volume = "46",

pages = "885--908",

journal = "Cellular Oncology",

issn = "2211-3436",

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TY - JOUR

T1 - Crosstalk between long noncoding RNA and microRNA in Cancer

AU - Bhattacharjee, Rahul

AU - Prabhakar, Neeraj

AU - Kumar, Lamha

AU - Bhattacharjee, Arkadyuti

AU - Kar, Sulagna

AU - Malik, Sumira

AU - Kumar, Dhruv

AU - Ruokolainen, Janne

AU - Negi, Arvind

AU - Jha, Niraj Kumar

AU - Kesari, Kavindra Kumar

PY - 2023/8

Y1 - 2023/8

N2 - miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management.

AB - miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management.

KW - Humans

KW - MicroRNAs/genetics

KW - RNA, Long Noncoding/genetics

KW - Neoplasms/genetics

KW - Neovascularization, Pathologic/genetics

KW - Epithelial-Mesenchymal Transition/genetics

KW - Gene Expression Regulation, Neoplastic

U2 - 10.1007/s13402-023-00806-9

DO - 10.1007/s13402-023-00806-9

M3 - Review Article or Literature Review

C2 - 37245177

SN - 2211-3436

VL - 46

SP - 885

EP - 908

JO - Cellular Oncology

JF - Cellular Oncology

IS - 4

ER -

Crosstalk between long noncoding RNA and microRNA in Cancer

Abstract

Keywords

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