Roles of vimentin in health and disease

Karen M Ridge; John E Eriksson; Milos Pekny; Robert D Goldman

doi:10.1101/gad.349358.122

Roles of vimentin in health and disease

Karen M Ridge, John E Eriksson, Milos Pekny, Robert D Goldman

Biochemistry and Cell Biology

Research output: Contribution to journal › Review Article or Literature Review › peer-review

71 Citations (Scopus)

54 Downloads (Pure)

Abstract

More than 27 yr ago, the vimentin knockout (Vim-/- ) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim-/- mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim-/- mice and cells derived from them.

Original language	English
Pages (from-to)	391-407
Number of pages	17
Journal	Genes and Development
Volume	36
Issue number	7-8
DOIs	https://doi.org/10.1101/gad.349358.122
Publication status	Published - 1 Apr 2022
MoE publication type	A2 Review article in a scientific journal

Keywords

Animals
Cell Physiological Phenomena
Intermediate Filaments/genetics
Mice
Vimentin/genetics

Access to Document

10.1101/gad.349358.122

Genes Dev.-2022-Ridge-391-407Final published version, 6.02 MBLicence: CC BY

https://urn.fi/URN:NBN:fi-fe2023020225508

Cite this

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title = "Roles of vimentin in health and disease",

abstract = "More than 27 yr ago, the vimentin knockout (Vim-/- ) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim-/- mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim-/- mice and cells derived from them.",

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doi = "10.1101/gad.349358.122",

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AU - Ridge, Karen M

AU - Eriksson, John E

AU - Pekny, Milos

AU - Goldman, Robert D

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Y1 - 2022/4/1

N2 - More than 27 yr ago, the vimentin knockout (Vim-/- ) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim-/- mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim-/- mice and cells derived from them.

AB - More than 27 yr ago, the vimentin knockout (Vim-/- ) mouse was reported to develop and reproduce without an obvious phenotype, implying that this major cytoskeletal protein was nonessential. Subsequently, comprehensive and careful analyses have revealed numerous phenotypes in Vim-/- mice and their organs, tissues, and cells, frequently reflecting altered responses in the recovery of tissues following various insults or injuries. These findings have been supported by cell-based experiments demonstrating that vimentin intermediate filaments (IFs) play a critical role in regulating cell mechanics and are required to coordinate mechanosensing, transduction, signaling pathways, motility, and inflammatory responses. This review highlights the essential functions of vimentin IFs revealed from studies of Vim-/- mice and cells derived from them.

KW - Animals

KW - Cell Physiological Phenomena

KW - Intermediate Filaments/genetics

KW - Mice

KW - Vimentin/genetics

U2 - 10.1101/gad.349358.122

DO - 10.1101/gad.349358.122

M3 - Review Article or Literature Review

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VL - 36

SP - 391

EP - 407

JO - Genes and Development

JF - Genes and Development

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ER -

Roles of vimentin in health and disease

Abstract

Keywords

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