TY - JOUR
T1 - Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens
AU - Pardhi, Dinesh M.
AU - Sen Karaman, Didem
AU - Timonen, Juri
AU - Wu, Wei
AU - Zhang, Qi
AU - Satija, Saurabh
AU - Mehta, Meenu
AU - Charbe, Nitin
AU - McCarron, Paul A.
AU - Tambuwala, Murtaza M.
AU - Bakshi, Hamid A.
AU - Negi, Poonam
AU - Aljabali, Alaa A.
AU - Dua, Kamal
AU - Chellappan, Dinesh K.
AU - Behera, Ajit
AU - Pathak, Kamla
AU - Watharkar, Ritesh B.
AU - Rautio, Jarkko
AU - Rosenholm, Jessica M.
PY - 2020/8/30
Y1 - 2020/8/30
N2 - This review details the antimicrobial applications of inorganic nanomaterials of mostly metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The review is subdivided into three main sections, of which the first describes the antimicrobial activity of inorganic nanomaterials against gram-positive, gram-negative and multidrug-resistant bacterial strains. The second section highlights the range of antimicrobial peptides and the drug resistance strategies employed by bacterial species to counter lethality. The final part discusses the role of antimicrobial peptide-decorated inorganic nanomaterials in the fight against bacterial strains that show resistance. General strategies for the preparation of antimicrobial peptides and their conjugation to nanomaterials are discussed, emphasizing the use of elemental and metallic oxide nanomaterials. Importantly, the permeation of antimicrobial peptides through the bacterial membrane is shown to aid the delivery of nanomaterials into bacterial cells. By judicious use of targeting ligands, the nanomaterial becomes able to differentiate between bacterial and mammalian cells and, thus, reduce side effects. Moreover, peptide conjugation to the surface of a nanomaterial will alter surface chemistry in ways that lead to reduction in toxicity and improvements in biocompatibility.
AB - This review details the antimicrobial applications of inorganic nanomaterials of mostly metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The review is subdivided into three main sections, of which the first describes the antimicrobial activity of inorganic nanomaterials against gram-positive, gram-negative and multidrug-resistant bacterial strains. The second section highlights the range of antimicrobial peptides and the drug resistance strategies employed by bacterial species to counter lethality. The final part discusses the role of antimicrobial peptide-decorated inorganic nanomaterials in the fight against bacterial strains that show resistance. General strategies for the preparation of antimicrobial peptides and their conjugation to nanomaterials are discussed, emphasizing the use of elemental and metallic oxide nanomaterials. Importantly, the permeation of antimicrobial peptides through the bacterial membrane is shown to aid the delivery of nanomaterials into bacterial cells. By judicious use of targeting ligands, the nanomaterial becomes able to differentiate between bacterial and mammalian cells and, thus, reduce side effects. Moreover, peptide conjugation to the surface of a nanomaterial will alter surface chemistry in ways that lead to reduction in toxicity and improvements in biocompatibility.
KW - Nanomaterial
KW - Antimicrobial
KW - Conjugates
KW - Antimicrobial peptides
KW - Antibiotics
U2 - 10.1016/j.ijpharm.2020.119531
DO - 10.1016/j.ijpharm.2020.119531
M3 - Article
SN - 0378-5173
VL - 586
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
M1 - 119531
ER -