Human sensorimotor beta event characteristics and aperiodic signal are highly heritable
Pauls, K. A. M., Salmela, E., Korsun, O., Kujala, J., Salmelin, R., & Renvall, H. (2024). Human sensorimotor beta event characteristics and aperiodic signal are highly heritable. Journal of Neuroscience, 44(5), Article e0265232023. https://doi.org/10.1523/jneurosci.0265-23.2023
Julkaistu sarjassa
Journal of NeuroscienceTekijät
Päivämäärä
2024Tekijänoikeudet
© 2023 the Authors
Individuals’ phenotypes, including the brain's structure and function, are largely determined by genes and their interplay. The resting brain generates salient rhythmic patterns that can be characterized non-invasively using functional neuroimaging such as magnetoencephalography (MEG). One of these rhythms, the somatomotor (‘rolandic’) beta rhythm, shows intermittent high amplitude ‘events’ that predict behavior across tasks and species. Beta rhythm is altered in neurological disease. The aperiodic (‘1/f’) signal present in electrophysiological recordings is also modulated by some neurological conditions and aging. Both sensorimotor beta and aperiodic signal could thus serve as biomarkers of sensorimotor function. Knowledge about the extent to which these brain functional measures are heritable could shed light on the mechanisms underlying their generation. We investigated the heritability and variability of human spontaneous sensorimotor beta rhythm events and aperiodic activity in 210 healthy male and female adult siblings’ spontaneous MEG activity. The most heritable trait was the aperiodic 1/f signal, with a heritability of 0.87 in the right hemisphere. Time-resolved beta event amplitude parameters were also highly heritable, whereas the heritabilities for overall beta power, peak frequency and measures of event duration remained nonsignificant. Human sensorimotor neural activity can thus be dissected into different components with variable heritability. We postulate that these differences partially reflect different underlying signal generating mechanisms. The 1/f signal and beta event amplitude measures may depend more on fixed, anatomical parameters, whereas beta event duration and its modulation reflect dynamic characteristics, guiding their use as potential disease biomarkers.
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Society for NeuroscienceISSN Hae Julkaisufoorumista
0270-6474Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/194487511
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AP has received funding from Helsinki University, the Research Council of Finland (grant number 350242) and the Sigrid Jusélius Foundation. ES has received funding from Jenny and Antti Wihuri Foundation and Ella and Georg Ehrnrooth Foundation. OK is funded by the Instrumentarium Science Foundation and Finnish Cultural Foundation. RS has received funding from the Research Council of Finland (grant numbers 315553 and 355407) and the Sigrid Jusélius Foundation. HR has received funding from the Research Council of Finland (grant numbers 127401, 321460 and 355409), Paulo Foundation, and the Finnish Cultural Foundation. ...Lisenssi
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