Early life factors and hippocampal functional connectivity in children with overweight/obesity
Solis‐Urra, P., Esteban‐Cornejo, I., Mora‐Gonzalez, J., Stillman, C., Contreras‐Rodriguez, O., Erickson, K. I., Catena, A., & Ortega, F. B. (2022). Early life factors and hippocampal functional connectivity in children with overweight/obesity. Pediatric Obesity, 18(3), Article e12998. https://doi.org/10.1111/ijpo.12998
Julkaistu sarjassa
Pediatric ObesityTekijät
Päivämäärä
2022Tekijänoikeudet
© 2022 World Obesity Federation.
Objective
We investigated the association of anthropometric neonatal data (birth length and birth weight) and breastfeeding practices (exclusive and any breastfeeding) with hippocampal functional connectivity and its academic implication in children with overweight/obesity.
Methods
Ninety six children with overweight/obesity aged 8–11 years (10.01 ± 1.14), from the ActiveBrains project were included in this cross-sectional study. Anthropometric neonatal data were collected from birth records, whereas breastfeeding practices were reported by parents. A 3.0 Tesla Siemens Magnetom Tim Trio system was used to acquire T1-weighted and resting-state functional magnetic resonance images. Academic performance was assessed by the Woodcock-Muñoz standardized test. Hippocampal seed-based methods with post-hoc regression analyses were performed. Analyses were considered significant when surpassing Family-Wise Error corrections.
Results
Birth weight showed a positive association with the connectivity between the hippocampus and the pre- and postcentral gyri, and the cerebellum. In addition, breastfeeding was negatively associated with the connectivity between the hippocampus and the primary motor cortex and the angular gyrus. Any breastfeeding, in turn, showed a positive association with the connectivity between the hippocampus and the middle temporal gyrus. None of the connectivity outcomes related to early life factors was coupled with better academic abilities (all p > 0.05).
Conclusions
Our findings suggest that birth weight at birth and breastfeeding are associated with hippocampal connectivity in children with overweight/obesity. Despite this, how the results relate to academic performance remains a matter of speculation. Our findings suggest that clinicians should recognize the importance early life factors for potentially avoiding consequences on offspring's brain development.
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Julkaisija
WileyISSN Hae Julkaisufoorumista
2047-6302Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/193407014
Metadata
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- Liikuntatieteiden tiedekunta [2957]
Lisätietoja rahoituksesta
This study was supported by the Spanish Ministry of Economy and Competitiveness (DEP2013-47540, DEP2016-79512-R, and DEP2017-91544-EXP), the European Regional Development Fund (ERDF), the European Commission (No 667302) and the Alicia Koplowitz Foundation. This study was partially funded by the UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme. Units of Scientific Excellence; Scientific Unit of Excellence on Excercise and Health (UCEES) and by the Regional Government of Andalusia, Regional Ministry of Economy, Knowledge, Entreprises and University and European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR. In addition, this study was further supported by the SAMID III network, RETICS, funded by the PN I + D + I 2017-2021 (Spain). PS-U is supported by a grant from ANID/BECAS Chile/72180543 and though a Margarita Salas grant from the Spanish Ministry Universities. IE-C is supported by the Spanish Ministry of Economy and Competitiveness (RTI2018-095284-J-100) and the Ministry of Science and Innovation (RyC2019-027287-1). J.M-G. has been supported by grants from the Spanish Ministry of Science and Innovation (FPU 14/06837) and is now supported by the Junta de Andalucía postdoctoral research grant. OCR is funded by a “Miguel Servet” contract (CP20/00165). ...Lisenssi
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