Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study
Turunen, Jenni; Tejesvi, Mysore V.; Paalanne, Niko; Pokka, Tytti; Amatya, Sajeen Bahadur; Mishra, Surbhi; Kaisanlahti, Anna; Reunanen, Justus; Tapiainen, Terhi (2023-08-17)
Turunen, Jenni
Tejesvi, Mysore V.
Paalanne, Niko
Pokka, Tytti
Amatya, Sajeen Bahadur
Mishra, Surbhi
Kaisanlahti, Anna
Reunanen, Justus
Tapiainen, Terhi
Springer
17.08.2023
Turunen, J., Tejesvi, M.V., Paalanne, N. et al. Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study. Pediatr Res 95, 135–145 (2024). https://doi.org/10.1038/s41390-023-02783-z
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© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
https://creativecommons.org/licenses/by/4.0/
© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi-fe20231011139721
https://urn.fi/URN:NBN:fi-fe20231011139721
Tiivistelmä
Abstract
Background:
The first-pass meconium has been suggested as a proxy for the fetal gut microbiota because it is formed in utero. This systematic review and cohort study investigated how pre- and perinatal factors influence the composition of the meconium microbiota.
Methods:
We performed the systematic review using Covidence by searching PubMed, Scopus, and Web of Science databases with the search terms “meconium microbiome” and “meconium microbiota”. In the cohort study, we performed 16 S rRNA gene sequencing on 393 meconium samples and analyzed the sequencing data using QIIME2.
Results:
Our systematic review identified 69 studies exploring prenatal factors, immediate perinatal factors, and microbial composition in relation to subsequent health of infants but gave only limited comparative evidence regarding factors related to the composition of the meconium microbiota. The cohort study pointed to a low-biomass microbiota consisting of the phyla Firmicutes, Proteobacteria and Actinobacteriota and the genera Staphylococcus, Escherichia-Shigella and Lactobacillus, and indicated that immediate perinatal factors affected the composition of the meconium microbiota more than did prenatal factors.
Conclusions:
This finding supports the idea that the meconium microbiota mostly starts developing during delivery.
Impact:
-It is unclear when the first-pass meconium microbiota develops, and what are the sources of the colonization.
-In this systematic review, we found 69 studies exploring prenatal factors, immediate perinatal factors, and microbial composition relative to subsequent health of infants, but there was no consensus on the factors affecting the meconium microbiota development.
-In this cohort study, immediate perinatal factors markedly affected the meconium microbiota development while prenatal factors had little effect on it.
-As the meconium microbiota composition was influenced by immediate perinatal factors, the present study supports the idea that the initial gut microbiota develops mainly during delivery.
Background:
The first-pass meconium has been suggested as a proxy for the fetal gut microbiota because it is formed in utero. This systematic review and cohort study investigated how pre- and perinatal factors influence the composition of the meconium microbiota.
Methods:
We performed the systematic review using Covidence by searching PubMed, Scopus, and Web of Science databases with the search terms “meconium microbiome” and “meconium microbiota”. In the cohort study, we performed 16 S rRNA gene sequencing on 393 meconium samples and analyzed the sequencing data using QIIME2.
Results:
Our systematic review identified 69 studies exploring prenatal factors, immediate perinatal factors, and microbial composition in relation to subsequent health of infants but gave only limited comparative evidence regarding factors related to the composition of the meconium microbiota. The cohort study pointed to a low-biomass microbiota consisting of the phyla Firmicutes, Proteobacteria and Actinobacteriota and the genera Staphylococcus, Escherichia-Shigella and Lactobacillus, and indicated that immediate perinatal factors affected the composition of the meconium microbiota more than did prenatal factors.
Conclusions:
This finding supports the idea that the meconium microbiota mostly starts developing during delivery.
Impact:
-It is unclear when the first-pass meconium microbiota develops, and what are the sources of the colonization.
-In this systematic review, we found 69 studies exploring prenatal factors, immediate perinatal factors, and microbial composition relative to subsequent health of infants, but there was no consensus on the factors affecting the meconium microbiota development.
-In this cohort study, immediate perinatal factors markedly affected the meconium microbiota development while prenatal factors had little effect on it.
-As the meconium microbiota composition was influenced by immediate perinatal factors, the present study supports the idea that the initial gut microbiota develops mainly during delivery.
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