Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues
Marttila, Saara; Tamminen, Hely; Rajić, Sonja; Mishra, Pashupati P; Lehtimäki, Terho; Raitakari, Olli; Kähönen, Mika; Kananen, Laura; Jylhävä, Juulia; Hägg, Sara; Delerue, Thomas; Peters, Annette; Waldenberger, Melanie; Kleber, Marcus E; März, Winfried; Luoto, Riitta; Raitanen, Jani; Sillanpää, Elina; Laakkonen, Eija K; Heikkinen, Aino; Ollikainen, Miina; Raitoharju, Emma (2022-10)
Marttila, Saara
Tamminen, Hely
Rajić, Sonja
Mishra, Pashupati P
Lehtimäki, Terho
Raitakari, Olli
Kähönen, Mika
Kananen, Laura
Jylhävä, Juulia
Hägg, Sara
Delerue, Thomas
Peters, Annette
Waldenberger, Melanie
Kleber, Marcus E
März, Winfried
Luoto, Riitta
Raitanen, Jani
Sillanpää, Elina
Laakkonen, Eija K
Heikkinen, Aino
Ollikainen, Miina
Raitoharju, Emma
10 / 2022
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202212099023
https://urn.fi/URN:NBN:fi:tuni-202212099023
Kuvaus
Peer reviewed
Tiivistelmä
Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.
Kokoelmat
- TUNICRIS-julkaisut [16983]