Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Lifelines cohort study; Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J.; Moore, Tim; Hemerich, Daiane; Cornelis, Marilyn C.; Mazzaferro, Eugenia; Broos, Siacia; Ahluwalia, Tarunveer S.; Bartz, Traci M.; Bentley, Amy R.; Bielak, Lawrence F.; Chong, Mike; Chu, Audrey Y.; Berry, Diane; Dorajoo, Rajkumar; Dueker, Nicole D.; Kasbohm, Elisa; Feenstra, Bjarke; Feitosa, Mary F.; Gieger, Christian; Graff, Mariaelisa; Hall, Leanne M.; Haller, Toomas; Hartwig, Fernando P.; Hillis, David A.; Huikari, Ville; Heard-Costa, Nancy; Holzapfel, Christina; Jackson, Anne U.; Johansson, Åsa; Jørgensen, Anja Moltke; Kaakinen, Marika A.; Karlsson, Robert; Kerr, Kathleen F.; Kim, Boram; Koolhaas, Chantal M.; Kutalik, Zoltan; Lagou, Vasiliki; Lind, Penelope A.; Lorentzon, Mattias; Lyytikäinen, Leo Pekka; Mangino, Massimo; Metzendorf, Christoph; Monroe, Kristine R.; Pacolet, Alexander; Pérusse, Louis; Kähönen, Mika; Kuusisto, Johanna; Lehtimäki, Terho (2022)
Lifelines cohort study
Wang, Zhe
Emmerich, Andrew
Pillon, Nicolas J.
Moore, Tim
Hemerich, Daiane
Cornelis, Marilyn C.
Mazzaferro, Eugenia
Broos, Siacia
Ahluwalia, Tarunveer S.
Bartz, Traci M.
Bentley, Amy R.
Bielak, Lawrence F.
Chong, Mike
Chu, Audrey Y.
Berry, Diane
Dorajoo, Rajkumar
Dueker, Nicole D.
Kasbohm, Elisa
Feenstra, Bjarke
Feitosa, Mary F.
Gieger, Christian
Graff, Mariaelisa
Hall, Leanne M.
Haller, Toomas
Hartwig, Fernando P.
Hillis, David A.
Huikari, Ville
Heard-Costa, Nancy
Holzapfel, Christina
Jackson, Anne U.
Johansson, Åsa
Jørgensen, Anja Moltke
Kaakinen, Marika A.
Karlsson, Robert
Kerr, Kathleen F.
Kim, Boram
Koolhaas, Chantal M.
Kutalik, Zoltan
Lagou, Vasiliki
Lind, Penelope A.
Lorentzon, Mattias
Lyytikäinen, Leo Pekka
Mangino, Massimo
Metzendorf, Christoph
Monroe, Kristine R.
Pacolet, Alexander
Pérusse, Louis
Kähönen, Mika
Kuusisto, Johanna
Lehtimäki, Terho
2022
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202211248620
https://urn.fi/URN:NBN:fi:tuni-202211248620
Kuvaus
Peer reviewed
Tiivistelmä
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.
Kokoelmat
- TUNICRIS-julkaisut [16977]