Infection With Escherichia Coli Pathotypes Is Associated With Biomarkers of Gut Enteropathy and Nutritional Status Among Malnourished Children in Bangladesh
Gazi, Md Amran; Alam, Md Ashraful; Fahim, Shah Mohammad; Wahid, Barbie Zaman; Khan, Shaila Sharmeen; Islam, Md Ohedul; Hasan, Md Mehedi; Hasan, S. M.Tafsir; Das, Subhasish; Mahfuz, Mustafa; Haque, Rashidul; Ahmed, Tahmeed (2022-07-06)
Gazi, Md Amran
Alam, Md Ashraful
Fahim, Shah Mohammad
Wahid, Barbie Zaman
Khan, Shaila Sharmeen
Islam, Md Ohedul
Hasan, Md Mehedi
Hasan, S. M.Tafsir
Das, Subhasish
Mahfuz, Mustafa
Haque, Rashidul
Ahmed, Tahmeed
06.07.2022
901324
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202208056245
https://urn.fi/URN:NBN:fi:tuni-202208056245
Kuvaus
Peer reviewed
Tiivistelmä
Escherichia coli (E. coli) pathotypes are the most common cause of diarrhea, especially in developing countries. Environmental Enteric Dysfunction (EED) is presumed to be the result of infection with one or more pathotypes and can affect intestinal health and childhood growth. We sought to investigate the association of E. coli pathotypes infection with biomarkers of EED and nutritional status among slum-dwelling malnourished children in Bangladesh. This study comprised a total of 1050 stunted and at risk of stunting children. TaqMan Array Card assays were used to determine the presence of E. coli pathotypes in feces. Prevalence of infection with EAEC was highest (68.8%) in this cohort of children, followed by EPEC (55.9%), ETEC (44%), Shigella/EIEC (19.4%) and STEC (3.2%). The levels of myeloperoxidase and calprotectin were significantly higher in EAEC (P=0.02 and P=0.04), EPEC (P=0.02 and P=0.03) and Shigella/EIEC (P=0.05 and P=0.02) positive participants while, only calprotectin was significantly higher in ETEC (P=0.01) positive participants. Reg1B was significantly higher in participants with EAEC (P=0.004) while, neopterin levels were significantly lower in ETEC (P=0.003) and Shigella/EIEC (P=0.003) positive cases. A significant positive relationship was observed between EAEC and fecal levels of Reg1B (β = 0.28; 95% CI = 0.12, 0.43; p-value<0.001). Besides, ETEC was found to be positively and significantly associated with the levels of calprotectin (β = 0.14; 95 percent CI = 0.01, 0.26; p-value=0.037) and negatively with neopterin (β = -0.16; 95% CI = -0.30, -0.02; p-value=0.021). On the other hand, infection with EPEC was found to be negatively associated with length-for-age (β = -0.12; 95% CI = -0.22, -0.03; p-value=0.011) and weight-for-age (β = -0.11; 95% CI = -0.22, -0.01; p-value=0.037). The study findings suggest that infection with certain E. coli pathotypes (EAEC and ETEC) influences gut health and EPEC is associated with linear growth and underweight in Bangladeshi children.
Kokoelmat
- TUNICRIS-julkaisut [16983]