Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life
Syrjänen, Stina; Waterboer, Tim; Rintala, Marjut; Pawlita, Michael; Syrjänen, Kari; Louvanto, Karolina; Grenman, Seija (2022-02)
Syrjänen, Stina
Waterboer, Tim
Rintala, Marjut
Pawlita, Michael
Syrjänen, Kari
Louvanto, Karolina
Grenman, Seija
02 / 2022
2227
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202204294117
https://urn.fi/URN:NBN:fi:tuni-202204294117
Kuvaus
Peer reviewed
Tiivistelmä
To assess the dynamics of human papillomavirus (HPV) serology, we analyzed HPV6-,11-,16-,18-, and 45 antibodies in infants during the first 36 months of their life. Serial serum samples of 276/327 mother–child pairs were collected at baseline (mothers) and at months 1, 2, 6, 12, 24 and 36 (offspring), and tested for HPVL1-antibodies using the GST-L1 assay. Concordance between maternal and infant HPV-antibody levels remained high until month-6 (p < = 0.001), indicating maternal antibody transfer. At 1 month, 40–62% of the infants tested seropositive to any of the 5 HPV-types. Between 1–3 years of age, 53% (58/109) of the children born to HPV-seronegative mothers tested HPV-seropositive. Times to positive seroconversion varied between13.4 and 18.7 months, and times to negative seroconversion (decay) between 8.5 and 9.9 months. Significant independent predictors of infants’ seroconversion to LR-HPV were hand warts and mother’s history of oral warts and seroconversion to LR-HPV. No predictors of seroconversion to HR-HPV were identified. Maternal HPV-IgG-antibodies are transferred to her offspring and remain detectable for 6 months, corroborating the IgG molecule’s half-life. Seroconversion to HPV-genotypes 6, 11, 16 and 18 was confirmed among children born to HPV-seronegative mothers, implicating an immune response to these HPV-genotypes during early infancy.
Kokoelmat
- TUNICRIS-julkaisut [16726]