INSM1, a novel biomarker for detection of neuroendocrine neoplasms : Cytopathologists’ view
Maleki, Zahra; Nadella, Akash; Nadella, Mohnish; Patel, Gopi; Patel, Shivni; Kholová, Ivana (2021-11)
Maleki, Zahra
Nadella, Akash
Nadella, Mohnish
Patel, Gopi
Patel, Shivni
Kholová, Ivana
11 / 2021
2172
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202112129138
https://urn.fi/URN:NBN:fi:tuni-202112129138
Kuvaus
Peer reviewed
Tiivistelmä
Background: Insulinoma-associated protein 1 (INSM1) has been considered as a novel immunostain for neuroendocrine tumors (NETs) and is hypothesized to be more reliable than first-generation NET biomarkers, such as CGA (chromogranin A), SYP (synaptophysin) and CD56 (neural cell adhesion molecule). In this review, we summarize existing literature on INSM1′ s reliability as an immunostain for detection of various NETs, its results in comparison to first-generation NET biomarkers, and its expression in both non-NETs and benign tissues/cells on cytology specimens (cell blocks/smears).
Kokoelmat
- TUNICRIS-julkaisut [16983]