Persistent skin symptoms after diagnosis and on a long-term gluten-free diet in dermatitis herpetiformis
Pasternack, Camilla; Hervonen, Kaisa; Mansikka, Eriika; Reunala, Timo; Collin, Pekka; Kaukinen, Katri; Salmi, Teea (2021)
Pasternack, Camilla
Hervonen, Kaisa
Mansikka, Eriika
Reunala, Timo
Collin, Pekka
Kaukinen, Katri
Salmi, Teea
2021
adv00555
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202110277865
https://urn.fi/URN:NBN:fi:tuni-202110277865
Kuvaus
Peer reviewed
Tiivistelmä
Dermatitis herpetiformis is a cutaneous manifestation of coeliac disease treated with a gluten-free diet. However, the itching and blistering rash alleviates slowly after gluten withdrawal and occasionally persists despite a long-term gluten-free diet. This study investigated the prevalence and factors associated with prolonged (i.e. > 2 years) and ongoing skin symptoms in 237 patients with dermatitis herpetiformis. Data were gathered from medical records and via questionnaires. Among patients with dermatitis herpetiformis, 38% had prolonged symptoms after diagnosis, and 14% had ongoing skin symptoms at follow-up (median duration of gluten-free diet 24 years). A severe rash at diagnosis was associated with both prolonged and ongoing cutaneous symptoms. In addition, patients with dermatitis herpetiformis with ongoing skin symptoms at follow-up had been on the dietary treatment for a shorter time (median duration 16 vs 25 years) and were less often on a strict diet (53% vs 78%) compared with patients with dermatitis herpetiformis without ongoing skin symptoms.
Kokoelmat
- TUNICRIS-julkaisut [16983]