Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus
SUMMIT Steering Committee; CARDIOGRAMplusC4D Steering Committee; van Zuydam, Natalie R; Ladenvall, Claes; Voight, Benjamin F; Strawbridge, Rona J; Fernandez-Tajes, Juan; Rayner, N William; Robertson, Neil R; Mahajan, Anubha; Vlachopoulou, Efthymia; Goel, Anuj; Kleber, Marcus E; Nelson, Christopher P; Kwee, Lydia Coulter; Esko, Tõnu; Mihailov, Evelin; Mägi, Reedik; Milani, Lili; Fischer, Krista; Kanoni, Stavroula; Kumar, Jitender; Song, Ci; Hartiala, Jaana A; Pedersen, Nancy L; Perola, Markus; Gieger, Christian; Peters, Annette; Qu, Liming; Willems, Sara M; Doney, Alex S F; Morris, Andrew D; Zheng, Yan; Sesti, Giorgio; Hu, Frank B; Qi, Lu; Laakso, Markku; Thorsteinsdottir, Unnur; Grallert, Harald; van Duijn, Cornelia; Reilly, Muredach P; Ingelsson, Erik; Deloukas, Panos; Kathiresan, Sek; Metspalu, Andres; Shah, Svati H; Sinisalo, Juha; Salomaa, Veikko; Hamsten, Anders; Samani, Nilesh J; März, Winfried; Hazen, Stanley L; Lehtimäki, Terho (2020-12)
SUMMIT Steering Committee
CARDIOGRAMplusC4D Steering Committee
van Zuydam, Natalie R
Ladenvall, Claes
Voight, Benjamin F
Strawbridge, Rona J
Fernandez-Tajes, Juan
Rayner, N William
Robertson, Neil R
Mahajan, Anubha
Vlachopoulou, Efthymia
Goel, Anuj
Kleber, Marcus E
Nelson, Christopher P
Kwee, Lydia Coulter
Esko, Tõnu
Mihailov, Evelin
Mägi, Reedik
Milani, Lili
Fischer, Krista
Kanoni, Stavroula
Kumar, Jitender
Song, Ci
Hartiala, Jaana A
Pedersen, Nancy L
Perola, Markus
Gieger, Christian
Peters, Annette
Qu, Liming
Willems, Sara M
Doney, Alex S F
Morris, Andrew D
Zheng, Yan
Sesti, Giorgio
Hu, Frank B
Qi, Lu
Laakso, Markku
Thorsteinsdottir, Unnur
Grallert, Harald
van Duijn, Cornelia
Reilly, Muredach P
Ingelsson, Erik
Deloukas, Panos
Kathiresan, Sek
Metspalu, Andres
Shah, Svati H
Sinisalo, Juha
Salomaa, Veikko
Hamsten, Anders
Samani, Nilesh J
März, Winfried
Hazen, Stanley L
Lehtimäki, Terho
12 / 2020
e002769
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202102031896
https://urn.fi/URN:NBN:fi:tuni-202102031896
Kuvaus
Peer reviewed
Tiivistelmä
BACKGROUND: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). METHODS: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D). RESULTS: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background. CONCLUSIONS: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.
Kokoelmat
- TUNICRIS-julkaisut [16929]