TY - JOUR
T1 - Relationship between liver fat content and lifestyle factors in adults with metabolic syndrome
AU - Laine, Saara
AU - Sjöros, Tanja
AU - Garthwaite, Taru
AU - Saarenhovi, Maria
AU - Kallio, Petri
AU - Löyttyniemi, Eliisa
AU - Vähä-Ypyä, Henri
AU - Sievänen, Harri
AU - Vasankari, Tommi
AU - Laitinen, Kirsi
AU - Houttu, Noora
AU - Saukko, Ekaterina
AU - Knuuti, Juhani
AU - Saunavaara, Virva
AU - Heinonen, Ilkka H.A.
N1 - Funding Information:
This study was conducted within the Centre of Excellence in Cardiovascular and Metabolic Research, supported by the Academy of Finland, the University of Turku, Turku University Hospital, and Åbo Akademi University. The authors thank the staff of Turku PET Centre, University of Turku, and the laboratory personnel in the Turku University Hospital Laboratory for their excellent technical assistance. The study was financially supported by Grants from Academy of Finland, Instrumentarium Science Foundation, the Finnish Cultural Foundation, the Juho Vainio Foundation, the Hospital District of Southwest Finland, the Yrjö Jahnsson Foundation, the Turku University Foundation and the Finnish Diabetes Research Foundation.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - The aim of this study was to investigate the associations between liver fat content (LFC), sedentary behaviour (SB), physical activity (PA), fitness, diet, body composition, and cardiometabolic risk factors in adults with metabolic syndrome. A total of 44 sedentary adults (mean age 58 [SD 7] years; 25 women) with overweight or obesity participated. LFC was assessed with magnetic resonance spectroscopy and imaging, SB and PA with hip-worn accelerometers (26 [SD 3] days), fitness by maximal bicycle ergometry, body composition by air displacement plethysmography and nutrient intake by 4-day food diaries. LFC was not independently associated with SB, PA or fitness. Adjusted for sex and age, LFC was associated with body fat%, body mass index, waist circumference, triglycerides, alanine aminotransferase, and with insulin resistance markers. There was and inverse association between LFC and daily protein intake, which persisted after further adjusment with body fat%. LFC is positively associated with body adiposity and cardiometabolic risk factors, and inversely with daily protein intake. SB, habitual PA or fitness are not independent modulators of LFC. However, as PA is an essential component of healthy lifestyle, it may contribute to liver health indirectly through its effects on body composition in adults with metabolic syndrome.
AB - The aim of this study was to investigate the associations between liver fat content (LFC), sedentary behaviour (SB), physical activity (PA), fitness, diet, body composition, and cardiometabolic risk factors in adults with metabolic syndrome. A total of 44 sedentary adults (mean age 58 [SD 7] years; 25 women) with overweight or obesity participated. LFC was assessed with magnetic resonance spectroscopy and imaging, SB and PA with hip-worn accelerometers (26 [SD 3] days), fitness by maximal bicycle ergometry, body composition by air displacement plethysmography and nutrient intake by 4-day food diaries. LFC was not independently associated with SB, PA or fitness. Adjusted for sex and age, LFC was associated with body fat%, body mass index, waist circumference, triglycerides, alanine aminotransferase, and with insulin resistance markers. There was and inverse association between LFC and daily protein intake, which persisted after further adjusment with body fat%. LFC is positively associated with body adiposity and cardiometabolic risk factors, and inversely with daily protein intake. SB, habitual PA or fitness are not independent modulators of LFC. However, as PA is an essential component of healthy lifestyle, it may contribute to liver health indirectly through its effects on body composition in adults with metabolic syndrome.
UR - http://www.scopus.com/inward/record.url?scp=85140266577&partnerID=8YFLogxK
U2 - 10.1038/s41598-022-22361-3
DO - 10.1038/s41598-022-22361-3
M3 - Article
C2 - 36261605
AN - SCOPUS:85140266577
SN - 2045-2322
VL - 12
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 17428
ER -