TY - JOUR
T1 - The in vitro synthesis of cellulose – A mini-review
AU - Lehrhofer, Anna F.
AU - Goto, Takaaki
AU - Kawada, Toshinari
AU - Rosenau, Thomas
AU - Hettegger, Hubert
N1 - Funding Information:
We would like to thank the University of Natural Resources and Life Sciences, Vienna (BOKU), the County of Lower Austria, and Lenzing AG for their financial support in the framework of the “Austrian Biorefinery Center Tulln” (ABCT) and the BOKU doctoral school “Advanced Biorefineries: Chemistry & Materials” (ABC&M). The financial support by Wood K plus (T.G.) and the GFF Gesellschaft für Forschungsförderung Niederösterreich m.b.H. (A.F.L. and H.H., project LSC20-002 ) is gratefully acknowledged.
Publisher Copyright:
© 2022 The Authors
PY - 2022/6/1
Y1 - 2022/6/1
N2 - The implementation of cellulose as a green alternative to classical polymers sparks research on the synthesis of defined derivatives of this biopolymer for various high-tech applications. Apart from the scientific challenge, the in vitro synthesis of cellulose using a bottom-up approach provides specimens with absolutely accurate substituent patterns and degrees of polymerization, not accessible from native cellulose. Synthetic cellulose exhibiting a comparably high degree of polymerization (DP) was obtained starting from cellobiose by biocatalytic synthesis implementing cellulase. Cationic ring-opening polymerization has been established in the last two decades, representing an excellent means of precise modification with regards to regio- and stereoselective substitution. This method rendered isotopically enriched cellulose as well as enantiomers of native cellulose (“L-cellulose”, “D,L-cellulose”) accessible. In this review, techniques for in vitro cellulose synthesis are summarized and critically compared – with a special focus on more recent developments. This is complemented by a brief overview of alternative enzymatic approaches.
AB - The implementation of cellulose as a green alternative to classical polymers sparks research on the synthesis of defined derivatives of this biopolymer for various high-tech applications. Apart from the scientific challenge, the in vitro synthesis of cellulose using a bottom-up approach provides specimens with absolutely accurate substituent patterns and degrees of polymerization, not accessible from native cellulose. Synthetic cellulose exhibiting a comparably high degree of polymerization (DP) was obtained starting from cellobiose by biocatalytic synthesis implementing cellulase. Cationic ring-opening polymerization has been established in the last two decades, representing an excellent means of precise modification with regards to regio- and stereoselective substitution. This method rendered isotopically enriched cellulose as well as enantiomers of native cellulose (“L-cellulose”, “D,L-cellulose”) accessible. In this review, techniques for in vitro cellulose synthesis are summarized and critically compared – with a special focus on more recent developments. This is complemented by a brief overview of alternative enzymatic approaches.
KW - Anhydroglucose
KW - Biopolymer
KW - Cellulose
KW - In vitro synthesis
KW - Polysaccharide
KW - Ring-opening polymerization
UR - http://www.scopus.com/inward/record.url?scp=85124532762&partnerID=8YFLogxK
U2 - 10.1016/j.carbpol.2022.119222
DO - 10.1016/j.carbpol.2022.119222
M3 - Review Article or Literature Review
C2 - 35287852
AN - SCOPUS:85124532762
SN - 0144-8617
VL - 285
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 119222
ER -