Fabrication and characterization of poly(decalactone) nanoemulsions using tailor-made surfactants for delivery of hydrophobic drugs
Pyrhönen, Jasmin (2022)
Pyrhönen, Jasmin
2022
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi-fe2022060242295
https://urn.fi/URN:NBN:fi-fe2022060242295
Tiivistelmä
Delivery of hydrophobic drugs is a challenging field due to their poor aqueous solubility, whichaffects their bioavailability and pharmacological response. Nanoemulsion is a heterogeneous system of two immiscible liquids stabilized by surfactants, which has been widely utilized to enhance the aqueous solubility of drugs. Preparation of nanoemulsions using a hydrophobic oily polymer as a dispersed phase has its own advantage compared to conventional oils, such as high stability and ease of fabrication. However, the compatibility between hydrophobic drugs and polymer has a direct impact on the drug loading efficiency and thus, the aim of this work was to utilize insights obtained from molecular dynamics (MD) simulations to help predicting the miscibility of a polymeric nanoemulsion formulation with different drug molecules. The MD-calculated Hildebrand solubility parameters was used to screen for the best polymer-drug combinations. Later, the formulations were experimentally prepared to verify the simulation results. In addition, the effect of an in-house surfactant was compared with a commercially available surfactant. The MD simulation results were successfully proved in lab scale, and the use of the in-house-made surfactant in smaller quantities gave trustworthy results for a stable nanoemulsion with a high drug load.
Kokoelmat
- 317 Farmasia [19]