TY - JOUR
T1 - Polysaccharide-and β-cyclodextrin-based chiral selectors for enantiomer resolution
T2 - Recent developments and applications
AU - Bui, Cuong Viet
AU - Rosenau, Thomas
AU - Hettegger, Hubert
N1 - Funding Information:
We would like to thank the University of Natural Resources and Life Sciences, Vienna (BOKU) and the County of Lower Austria for their financial support in the framework of the Aus-trian Biorefinery Center Tulln (ABCT) and the BOKU doctoral school ?Advanced Biorefineries? Chemistry & Materials? (ABC&M). C.V.B. was also supported by the ASEAN-European Academic University Network (ASEA-UNINET, Ernst Mach Grant, ICM-2019-13801).
Funding Information:
Funding: We would like to thank the University of Natural Resources and Life Sciences, Vienna (BOKU) and the County of Lower Austria for their financial support in the framework of the Austrian Biorefinery Center Tulln (?BCT) and the BOKU doctoral school “?dvanced Biorefineries— Chemistry & Materials” (ABC&M). C.V.B. was also supported by the ASEAN-European Academic University Network (ASEA-UNINET, Ernst Mach Grant, ICM-2019-13801).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/7/2
Y1 - 2021/7/2
N2 - Polysaccharides, oligosaccharides, and their derivatives, particularly of amylose, cellu-lose, chitosan, and β-cyclodextrin, are well-known chiral selectors (CSs) of chiral stationary phases (CSPs) in chromatography, because they can separate a wide range of enantiomers. Typically, such CSPs are prepared by physically coating, or chemically immobilizing the polysaccharide and β-cy-clodextrin derivatives onto inert silica gel carriers as chromatographic support. Over the past few years, new chiral selectors have been introduced, and progressive methods to prepare CSPs have been exploited. Also, chiral recognition mechanisms, which play a crucial role in the investigation of chiral separations, have been better elucidated. Further insights into the broad functional performance of commercially available chiral column materials and/or the respective newly developed chiral phase materials on enantiomeric separation (ES) have been gained. This review summarizes the recent developments in CSs, CSP preparation, chiral recognition mechanisms, and enantiomeric separation methods, based on polysaccharides and β-cyclodextrins as CSs, with a focus on the years 2019–2020 of this rapidly developing field.
AB - Polysaccharides, oligosaccharides, and their derivatives, particularly of amylose, cellu-lose, chitosan, and β-cyclodextrin, are well-known chiral selectors (CSs) of chiral stationary phases (CSPs) in chromatography, because they can separate a wide range of enantiomers. Typically, such CSPs are prepared by physically coating, or chemically immobilizing the polysaccharide and β-cy-clodextrin derivatives onto inert silica gel carriers as chromatographic support. Over the past few years, new chiral selectors have been introduced, and progressive methods to prepare CSPs have been exploited. Also, chiral recognition mechanisms, which play a crucial role in the investigation of chiral separations, have been better elucidated. Further insights into the broad functional performance of commercially available chiral column materials and/or the respective newly developed chiral phase materials on enantiomeric separation (ES) have been gained. This review summarizes the recent developments in CSs, CSP preparation, chiral recognition mechanisms, and enantiomeric separation methods, based on polysaccharides and β-cyclodextrins as CSs, with a focus on the years 2019–2020 of this rapidly developing field.
KW - Amylose
KW - Cellulose
KW - Chiral selector
KW - Chiral stationary phase
KW - Chromatography
KW - Cyclodex-trin
KW - Enantiomer separation
KW - Polysaccharide
UR - http://www.scopus.com/inward/record.url?scp=85111100489&partnerID=8YFLogxK
U2 - 10.3390/molecules26144322
DO - 10.3390/molecules26144322
M3 - Review Article or Literature Review
C2 - 34299597
AN - SCOPUS:85111100489
SN - 1420-3049
VL - 26
JO - Molecules
JF - Molecules
IS - 14
M1 - 4322
ER -