Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster
Munkevics Maris; Krams Ronalds; Popovs Sergejs; de Bivort Benjamin L; Krams Indrikis A; Rantala Markus J; Makrna Janis; Jõers Priit; Krama Tatjana; Trakimas Giedrius; Elferts Didzis
Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster
Munkevics Maris
Krams Ronalds
Popovs Sergejs
de Bivort Benjamin L
Krams Indrikis A
Rantala Markus J
Makrna Janis
Jõers Priit
Krama Tatjana
Trakimas Giedrius
Elferts Didzis
FRONTIERS MEDIA SA
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021093048621
https://urn.fi/URN:NBN:fi-fe2021093048621
Tiivistelmä
When organisms' environmental conditions vary unpredictably in time, it can be advantageous for individuals to hedge their phenotypic bets. It has been shown that a bet-hedging strategy possibly underlies the high inter-individual diversity of phototactic choice in Drosophila melanogaster. This study shows that fruit flies from a population living in a boreal and relatively unpredictable climate have more variable variable phototactic biases than fruit flies from a more stable tropical climate, consistent with bet-hedging theory. We experimentally show that phototactic variability of D. melanogaster is regulated by the neurotransmitter serotonin (5-HT), which acts as a suppressor of the variability of phototactic choices. When fed 5-HT precursor, boreal flies exhibited lower variability, and they were insensitive to 5-HT inhibitor. The opposite pattern was seen in the tropical flies. Thus, the reduction of 5-HT in fruit flies' brains may be the mechanistic basis of an adaptive bet-hedging strategy in a less predictable boreal climate.
Kokoelmat
- Rinnakkaistallenteet [19207]