Tertiary lymphoid structures associate with improved survival in early oral tongue cancer
Almangush, Alhadi; Bello, Ibrahim O.; Elseragy, Amr; Hagström, Jaana; Haglund, Caj; Kowalski, Luiz Paulo; Nieminen, Pentti; Coletta, Ricardo D.; Mäkitie, Antti A.; Salo, Tuula; Leivo, Ilmo (2022-10-30)
Almangush, A., Bello, I.O., Elseragy, A. et al. Tertiary lymphoid structures associate with improved survival in early oral tongue cancer. BMC Cancer 22, 1108 (2022). https://doi.org/10.1186/s12885-022-10208-z
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https://urn.fi/URN:NBN:fi-fe2023070586499
Tiivistelmä
Abstract
Background: The clinical significance of tertiary lymphoid structures (TLSs) is not well-documented in early oral tongue squamous cell carcinoma (OTSCC).
Methods: A total of 310 cases of early (cT1-2N0) OTSCC were included in this multicenter study. Assessment of TLSs was conducted on hematoxylin and eosin-stained sections. TLSs were assessed both in the central part of the tumor and at the invasive front area.
Results: The presence of TLSs associated with improved survival of early OTSCC as presented by Kaplan–Meier survival analyses for disease-specific survival (P = 0.01) and overall survival (P = 0.006). In multivariable analyses, which included conventional prognostic factors, the absence of TLSs associated with worse disease-specific survival with a hazard ratio (HR) of 1.96 (95% CI 1.09–3.54; P = 0.025) and poor overall survival (HR 1.66, 95% CI 1.11–2.48; P = 0.014).
Conclusion: Histological evaluation of TLSs predicts survival in early OTSCC. TLSs showed superior prognostic power independent of routine WHO grading and TNM staging system.
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