Methodological changes in the field of paleogenetics
Danielewski, Mikołaj; Żuraszek, Joanna; Zielińska, Aleksandra; Herzig, Karl-Heinz; Słomski, Ryszard; Walkowiak, Jarosław; Wielgus, Karolina (2023-01-16)
Danielewski, M., Żuraszek, J., Zielińska, A., Herzig, K.-H., Słomski, R., Walkowiak, J., & Wielgus, K. (2023). Methodological Changes in the Field of Paleogenetics. Genes, 14(1), 234. https://doi.org/10.3390/genes14010234
© 2023 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2023040535159
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Abstract
Paleogenetics has significantly changed since its inception almost forty years ago. Initially, molecular techniques available to the researchers offered minimal possibilities for ancient DNA analysis. The subsequent expansion of the scientific tool cabinet allowed for more remarkable achievements, combined has with the newfound popularity of this budding field of science. Finally, a breakthrough was made with the development of next-generation sequencing (NGS) technologies and the update of DNA isolation protocols, through which even very fragmented aDNA samples could be used to sequence whole genomes. In this paper, we review the achievements made thus far and compare the methodologies utilized in this field of science, discussing their benefits and challenges.
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