Elevated one-hour post-load glucose is independently associated with albuminuria : a cross-sectional population study
Saunajoki, Anni; Auvinen, Juha; Bloigu, Aini; Saramies, Jouko; Tuomilehto, Jaakko; Uusitalo, Hannu; Hussi, Esko; Cederberg-Tamminen, Henna; Suija, Kadri; Keinänen-Kiukaanniemi, Sirkka; Timonen, Markku (2022-07-15)
Saunajoki, A., Auvinen, J., Bloigu, A., Saramies, J., Tuomilehto, J., Uusitalo, H., Hussi, E., Cederberg-Tamminen, H., Suija, K., Keinänen-Kiukaanniemi, S., & Timonen, M. (2022). Elevated One-Hour Post-Load Glucose Is Independently Associated with Albuminuria: A Cross-Sectional Population Study. Journal of Clinical Medicine, 11(14), 4124. https://doi.org/10.3390/jcm11144124
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe2022111866156
Tiivistelmä
Abstract
The purpose of this study was to examine and compare the associations between albuminuria and fasting (FPG), 1 h post-load (1 h PG) and 2 h post-load plasma glucose (2 h PG) in an oral glucose tolerance test (OGTT). A total of 496 people free of known diabetes (mean age 72 years) participated in the examinations including the OGTT with plasma glucose measurements at 0, 1, and 2 h and levels of HbA1c. Albuminuria was determined by the urinary albumin-to-creatinine ratio and was defined as ≥3.0 mg/mmol. Compared with those without albuminuria, participants with albuminuria had significantly higher 1 h PG and 2 h PG levels, but not FPG or HbA1c levels. An elevated 1 h PG increased the estimated odds ratio of albuminuria more than three times in people with prediabetic 1 h PG (8.6–11.5 mmol/L: OR 3.60; 95% CI 1.70–7.64) and diabetic 1 h PG (≥11.6 mmol/L: OR 3.05; 95% CI 1.29–7.23). After adjusting for blood pressure and age, the association of elevated 1 h PG with albuminuria remained significant. Prediabetic or diabetic FPG, 2 h PG, or HbA1c did not have a statistically significant association with albuminuria. These findings suggest that 1 h PG seems to be the best glycemic parameter and is useful in recognizing persons with an elevated risk of early kidney disease due to hyperglycemia.
Kokoelmat
- Avoin saatavuus [31995]