Female patients with follicular lymphoma have a better prognosis if primary remission lasts over 24 months
Rajamäki, Aino; Sunela, Kaisa; Prusila, Roosa E. I.; Kuusisto, Milla E. L.; Mercadal, Santiago; Selander, Tuomas; Kuitunen, Hanne; Pollari, Marjukka; Jantunen, Esa; Nystrand, Ilja; Sancho, Juan-Manuel; Sorigue, Marc; Kuittinen, Outi (2021-02-05)
Aino Rajamäki, Kaisa Sunela, Roosa E. I. Prusila, Milla E. L. Kuusisto, Santiago Mercadal, Tuomas Selander, Hanne Kuitunen, Marjukka Pollari, Esa Jantunen, Ilja Nystrand, Juan-Manuel Sancho, Marc Sorigue & Outi Kuittinen (2021) Female patients with follicular lymphoma have a better prognosis if primary remission lasts over 24 months, Leukemia & Lymphoma, 62:7, 1639-1647, DOI: https://doi.org/10.1080/10428194.2021.1872073
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed,or built upon in any way.
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://urn.fi/URN:NBN:fi-fe2021102151898
Tiivistelmä
Abstract
Findings regarding the role of sex in follicular lymphoma (FL) are contradictory and the prognostic value of sex among patients with early progression of disease (POD) remains unclear. We collected real-life data from nine hospitals in Finland and Spain including 1020 FL patients to study the influence of sex on disease outcome. The median follow-up duration was 67 months (range 0–226 months). Female patients showed better progression-free survival (PFS) (hazard ratio [HR], 0.720; 95% confidence interval [CI], 0.588–0.881), disease-specific survival (DSS) (HR, 0.653; 95% CI, 0.448–0.951), and overall survival (OS) (HR, 0.653; 95% CI, 0.501–0.853) than male patients. However, there were no significant sex differences in prognosis in patients with early POD. This study strengthens the understanding that male sex is an adverse prognostic factor for FL. However, this difference does not apply to patients with early POD.
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