Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts
Kiiskilä, Jukka; Jokelainen, Jari; Kytövuori, Laura; Mikkola, Ilona; Härkönen, Pirjo; Keinänen-Kiukaanniemi, Sirkka; Majamaa, Kari (2021-01-22)
Kiiskilä, J., Jokelainen, J., Kytövuori, L. et al. Association of mitochondrial DNA haplogroups J and K with low response in exercise training among Finnish military conscripts. BMC Genomics 22, 75 (2021). https://doi.org/10.1186/s12864-021-07383-x
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https://urn.fi/URN:NBN:fi-fe2021042211335
Tiivistelmä
Abstract
Background: We have previously suggested that some of the mutations defining mitochondrial DNA (mtDNA) haplogroups J and K produce an uncoupling effect on oxidative phosphorylation and thus are detrimental for elite endurance performance. Here, the association between haplogroups J and K and physical performance was determined in a population-based cohort of 1036 Finnish military conscripts.
Results: Following a standard-dose training period, excellence in endurance performance was less frequent among subjects with haplogroups J or K than among subjects with non-JK haplogroups (p = 0.041), and this finding was more apparent among the best-performing subjects (p < 0.001).
Conclusions: These results suggest that mtDNA haplogroups are one of the genetic determinants explaining individual variability in the adaptive response to endurance training, and mtDNA haplogroups J and K are markers of low-responders in exercise training.
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