Impact of astroprincin (FAM171A1) expression in oral tongue cancer
Wahab, Awais; Almangush, Alhadi; Andersson, Leif C.; Nieminen, Pentti; Salo, Tuula (2020-11-05)
Wahab A, Almangush A, Andersson LC, Nieminen P and Salo T (2020) Impact of Astroprincin (FAM171A1) Expression in Oral Tongue Cancer. Front. Oral. Health 1:599421. doi: 10.3389/froh.2020.599421
© 2020 Wahab, Almangush, Andersson, Nieminen and Salo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
https://creativecommons.org/licenses/by/4.0/
https://urn.fi/URN:NBN:fi-fe202101111505
Tiivistelmä
Abstract
Astroprincin (APCN, FAM171A1) is a recently characterized transmembrane glycoprotein that is abundant in brain astrocytes and is overexpressed in some tumors. However, the expression and role of APCN is unknown in oral tongue squamous cell carcinoma (OTSCC). Aim of this study was to investigate the expression of APCN in OTSCC tissue samples and to analyze possible association of APCN with clinicopathological features and survival rates. This study included 76 patients treated for OTSCC. Expression of APCN in OTSCC tissue sections was examined by immunohistochemistry with a rabbit polyclonal antibody (MAP346) against APCN. All tumors were scored for intensity and percentage of APCN staining at the superficial, middle, and invasive front areas. High expression of APCN was significantly associated with increased tumor size (P = 0.013) and with OTSCC recurrence (P = 0.026). In this pilot study, we observed that the amount of APCN is associated with the size and recurrence of OTSCC. This finding suggests a role of APCN during OTSCC progression.
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