Occurrence of pollen season at the end of the first trimester predicts clinical atopic diseases in the offspring : a Finnish population-based study
Pyrhönen, Kaisa; Kulmala, Petri (2020-01-29)
Kaisa Pyrhönen, Petri Kulmala, Occurrence of pollen season at the end of the first trimester predicts clinical atopic diseases in the offspring: A Finnish population-based study, International Journal of Hygiene and Environmental Health, Volume 225, 2020, 113452, ISSN 1438-4639, https://doi.org/10.1016/j.ijheh.2020.113452
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://urn.fi/URN:NBN:fi-fe2020083164681
Tiivistelmä
Abstract
Objective: To evaluate the association between potential exposure to different pollen concentrations at the 11th fetal week and subsequent clinical atopic diseases.
Study design and setting: Parents of 1- to 4-year-old children (N = 3035) returned a questionnaire regarding physician-diagnosed atopic diseases. The children were born between 2001 and 2005 in the province of South Karelia, Finland. Results of allergy tests were collected from patient records in the area.
Results: The prevalence of atopic diseases with sensitisation was higher in children whose 11th fetal week occurred during pollen rather than non-pollen season: atopic eczema 6.3% vs. 4.3% (adjusted odds ratio, aOR 1.58, 95% CI 1.10─2.28), food allergy 5.7% vs. 3.9% (1.63; 1.12─2.38), respiratory allergy or asthma 3.7% vs. 2.2% (2.03; 1.24─3.33) and any atopic diseases 7.4% vs. 5.5% (1.48; 1.07─2.05), respectively. Respectively, the prevalence was higher in the children exposed to high rather than low tree pollen concentrations (>1000 vs. <10 particles/m³) at the 11th fetal week: 12.1% vs. 4.4% (3.35; 1.89─5.95), 12.1% vs. 3.9% (3.77; 2.11─6.72), 4.7% vs. 2.5% (2.95; 1.21─7.20) and 14.0% vs. 5.7% (3.15; 1.86─5.35).
Conclusion: Coincidence of potential exposure to high tree pollen concentrations at the 11th fetal week is associated with subsequent clinical atopic diseases with sensitisation.
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