Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis
Hirvasniemi, J.; Thevenot, J.; Multanen, J.; Haapea, M.; Heinonen, A.; Nieminen, M. T.; Saarakkala, S. (2017-12-31)
J. Hirvasniemi, J. Thevenot, J. Multanen, M. Haapea, A. Heinonen, M.T. Nieminen, S. Saarakkala, Association between radiography-based subchondral bone structure and MRI-based cartilage composition in postmenopausal women with mild osteoarthritis, Osteoarthritis and Cartilage, Volume 25, Issue 12, 2017, Pages 2039-2046, ISSN 1063-4584, https://doi.org/10.1016/j.joca.2017.09.008
© 2017 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://urn.fi/URN:NBN:fi-fe2019061920988
Tiivistelmä
Abstract
Objective: Our aim was to investigate the relation between radiograph-based subchondral bone structure and cartilage composition assessed with delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T₂ relaxation time.
Design: Ninety-three postmenopausal women (Kellgren–Lawrence grade 0: n = 13, 1: n = 26, 2: n = 54) were included. Radiograph-based bone structure was assessed using entropy of the Laplacian-based image (ELap) and local binary patterns (ELBP), homogeneity indices of the local angles (HIAngles,mean, HIAngles,Perp, HIAngles,Paral), and horizontal (FDHor) and vertical fractal dimensions (FDVer). Mean dGEMRIC index and T₂ relaxation time of tibial cartilage were calculated to estimate cartilage composition.
Results: HIAngles,mean (rs = −0.22) and HIAngles,Paral (rs = −0.24) in medial subchondral bone were related (P < 0.05) to dGEMRIC index of the medial tibial cartilage. ELap (rs = −0.23), FDHor,0.34 mm (r = 0.21) and FDVer,0.68 mm (r = 0.24) in medial subchondral bone were related (P < 0.05) to T₂ relaxation time values of the medial tibial cartilage. FDHor at different scales in lateral subchondral bone were related (P < 0.01) to dGEMRIC index (r = 0.29–0.41) and T₂ values of lateral tibial cartilage (r = −0.28 to −0.36). FDVer at larger scales were related (P < 0.05) to dGEMRIC index (r = 0.24–0.25) and T₂ values of lateral tibial cartilage (r = −0.21). HIAngles,Paral (r = −0.25) and FDVer,0.68 mm (rs = 0.22) in the lateral tibial trabecular bone were related (P < 0.05) to dGEMRIC index of the lateral tibial cartilage.
Conclusion: Our results support the presumption that several tissues are affected in the early osteoarthritis (OA). Furthermore, they indicate that the detailed analysis of radiographs may serve as a complementary imaging tool for OA studies.
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