Vitamin D status and correlates of low vitamin D in schizophrenia, other psychoses and non-psychotic depression : the Northern Finland Birth Cohort 1966 Study
Ikonen, H.; Palaniswamy, S.; Nordström, T.; Järvelin, M.R.; Herzig, K.H.; Jääskeläinen, E.; Seppälä, J.; Miettunen, J.; Sebert, S. (2019-03-12)
H. Ikonen, S. Palaniswamy, T. Nordström, M.R. Järvelin, K.H. Herzig, E. Jääskeläinen, J. Seppälä, J. Miettunen, S. Sebert, Vitamin D status and correlates of low vitamin D in schizophrenia, other psychoses and non-psychotic depression – The Northern Finland Birth Cohort 1966 study, Psychiatry Research, Volume 279, 2019, Pages 186-194, ISSN 0165-1781, https://doi.org/10.1016/j.psychres.2019.02.060
© 2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://urn.fi/URN:NBN:fi-fe2019052016110
Tiivistelmä
Abstract
There is limited knowledge available on the association of vitamin D with psychiatric disorders in young adults. We aimed to investigate vitamin D levels and associating factors in schizophrenia, other psychoses and non-psychotic depression. We studied 4,987 participants from the Northern Finland Birth Cohort 1966 (31 years) with available serum 25-hydroxyvitamin D [25(OH)D] measurements. The final sample was divided into four groups: schizophrenia (n = 40), other psychoses (n = 24), non-psychotic depression (n = 264) and control (n = 4659). To account for the influence of environmental and technical covariates, we generated a vitamin D score variable with correction for season, sex, batch effect and latitude. We further examined how vitamin D levels correlate with anthropometric, lifestyle, socioeconomic and psychiatric measures. Neither serum 25(OH)D concentration nor vitamin D score differed between schizophrenia, other psychoses, non-psychotic depression and control group. The prevalence of vitamin D deficiency was 3.2%, insufficiency 25.5%, and sufficiency 71.3%. Low vitamin D score correlated with regular smoking in the group with schizophrenia. No difference was observed in other psychiatric conditions. We did not find any difference in vitamin D status between schizophrenia, psychoses, non-psychotic depression and control groups, but future studies are warranted to elucidate the role of vitamin D in psychiatric conditions.
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