Novel modeling of somatosensory evoked potentials for the assessment of spinal cord injury
Mir, Hasan; Al-Nashash, Hasan; Kortelainen, Jukka; All, Angelo (2017-05-02)
H. Mir, H. Al-Nashash, J. Kortelainen and A. All, "Novel Modeling of Somatosensory Evoked Potentials for the Assessment of Spinal Cord Injury," in IEEE Transactions on Biomedical Engineering, vol. 65, no. 3, pp. 511-520, March 2018. doi: 10.1109/TBME.2017.2700498
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https://urn.fi/URN:NBN:fi-fe2019041512353
Tiivistelmä
Abstract
Objective: Previous work has shown that differences in the somatosensory evoked potential (SEP) signals between a normal spinal pathway and spinal pathway affected by spinal cord injury (SCI) provide a means to study the degree of injury. This paper proposes a novel quantitative SCI assessment method using time-domain SEP signals.
Methods: A pruned and unstructured fit between SEP signals from a normal spinal pathway and a spinal pathway affected by SCI is developed using methods inspired by recent results in sparse reconstruction theory. The coefficients from the resulting fit are used to develop a quantitative assessment of SCI that is tested on actual SEP signals collected from rodents that have been subjected to partial and complete spinal cord transection.
Results: The proposed method provides a rich parametric measure that integrates SEP amplitude, time latency, and morphology, while exhibiting a high degree of correlation with existing subjective and quantitative SCI assessment methods.
Conclusion: The proposed SCI encapsulates a model of the injury to quantify SCI. Significance: The proposed SCI quantification method may be used to complement existing SCI assessment methods.
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