Celiac disease-type tissue transglutaminase autoantibody deposits in kidney biopsies of patients with IgA nephropathy
Nurmi, Rakel; Korponay-Szabó, Ilma; Laurila, Kaija; Huhtala, Heini; Niemelä, Onni; Mustonen, Jukka; Mäkelä, Satu; Kaukinen, Katri; Lindfors, Katri (2021-05)
Nurmi, Rakel
Korponay-Szabó, Ilma
Laurila, Kaija
Huhtala, Heini
Niemelä, Onni
Mustonen, Jukka
Mäkelä, Satu
Kaukinen, Katri
Lindfors, Katri
05 / 2021
1594
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202106085753
https://urn.fi/URN:NBN:fi:tuni-202106085753
Kuvaus
Peer reviewed
Tiivistelmä
An association between celiac disease and IgA nephropathy (IgAN) has been suggested. In celiac disease, in addition to circulating in serum, IgA-class tissue transglutaminase (tTG) autoanti-bodies are deposited in the small bowel mucosa and extraintestinal organs. In this case series of IgAN patients with or without celiac disease, we studied whether celiac disease-type IgA-tTG deposits occur in kidney biopsies. The study included nine IgAN patients, four of them with celiac disease. At the time of the diagnostic kidney biopsy serum tTG autoantibodies were measured and colocalization of IgA and tTG was investigated in the frozen kidney biopsies. Three IgAN patients with celiac disease had IgA-tTG deposits in the kidney even though in two of these the celiac disease diagnosis had been set years later. These deposits were not found in a patient with already diagnosed celiac disease following a gluten-free diet. Of the five non-celiac IgAN patients, three had IgA-tTG deposits in the kidney. We conclude that tTG-targeted IgA deposits can be found in the kidney biopsies of gluten-consuming IgAN patients but their specificity to celiac disease seems limited.
Kokoelmat
- TUNICRIS-julkaisut [16983]