Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children : A Birth Cohort Study
Mattila, Markus; Hakola, Leena; Niinistö, Sari; Tapanainen, Heli; Takkinen, Hanna-Mari; Ahonen, Suvi; Ilonen, Jorma; Toppari, Jorma; Veijola, Riitta; Knip, Mikael; Virtanen, Suvi M (2021)
Mattila, Markus
Hakola, Leena
Niinistö, Sari
Tapanainen, Heli
Takkinen, Hanna-Mari
Ahonen, Suvi
Ilonen, Jorma
Toppari, Jorma
Veijola, Riitta
Knip, Mikael
Virtanen, Suvi M
2021
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202105044352
https://urn.fi/URN:NBN:fi:tuni-202105044352
Kuvaus
Peer reviewed
Tiivistelmä
Our aim was to study the associations between maternal vitamin C and iron intake during pregnancy and the offspring's risk of developing islet autoimmunity and type 1 diabetes. The study was a part of the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) prospective birth cohort including children genetically at risk of type 1 diabetes born between 1997-2004. The diets of 4879 mothers in late pregnancy were assessed with a validated food frequency questionnaire. The outcomes were islet autoimmunity and type 1 diabetes. Cox proportional hazards regression analysis adjusted for energy, family history of diabetes, human leukocyte antigen (HLA) genotype and sex was used for statistical analyses. Total intake of vitamin C or iron from food and supplements was not associated with the risk of islet autoimmunity (vitamin C: HR 0.91: 95% CI (0.80, 1.03), iron: 0.98 (0.87, 1.10)) or type 1 diabetes (vitamin C: 1.01 (0.87, 1.17), iron: 0.92 (0.78, 1.08)), neither was the use of vitamin C or iron supplements associated with the outcomes. In conclusion, no association was found between maternal vitamin C or iron intake during pregnancy and the risk of islet autoimmunity or type 1 diabetes in the offspring.
Kokoelmat
- TUNICRIS-julkaisut [16983]