The TAXINOMISIS Project : A multidisciplinary approach for the development of a new risk stratification model for patients with asymptomatic carotid artery stenosis
all partners of the TAXINOMISIS Consortium; Timmerman, Nathalie; Galyfos, George; Sigala, Fragiska; Thanopoulou, Kalliopi; de Borst, Gert J; Davidovic, Lazar; Eckstein, Hans-Henning; Filipovic, Nenad; Grugni, Roberto; Kallmayer, Michael; de Kleijn, Dominique P V; Koncar, Igor; Mantzaris, Michalis D; Marchal, Elisabeth; Matsagkas, Miltiadis; Mutavdzic, Perica; Palombo, Domenico; Pasterkamp, Gerard; Potsika, Vassiliki T; Andreakos, Evangelos; Fotiadis, Dimitrios I; Lehtimäki, Terho; Mishra, Pashupati; Raitoharju, Emma; Mononen, Nina (2020)
all partners of the TAXINOMISIS Consortium
Timmerman, Nathalie
Galyfos, George
Sigala, Fragiska
Thanopoulou, Kalliopi
de Borst, Gert J
Davidovic, Lazar
Eckstein, Hans-Henning
Filipovic, Nenad
Grugni, Roberto
Kallmayer, Michael
de Kleijn, Dominique P V
Koncar, Igor
Mantzaris, Michalis D
Marchal, Elisabeth
Matsagkas, Miltiadis
Mutavdzic, Perica
Palombo, Domenico
Pasterkamp, Gerard
Potsika, Vassiliki T
Andreakos, Evangelos
Fotiadis, Dimitrios I
Lehtimäki, Terho
Mishra, Pashupati
Raitoharju, Emma
Mononen, Nina
2020
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tuni-202102011834
https://urn.fi/URN:NBN:fi:tuni-202102011834
Kuvaus
Peer reviewed
Tiivistelmä
INTRODUCTION: Asymptomatic carotid artery stenosis (ACAS) may cause future stroke and therefore patients with ACAS require best medical treatment. Patients at high risk for stroke may opt for additional revascularization (either surgery or stenting) but the future stroke risk should outweigh the risk for peri/post-operative stroke/death. Current risk stratification for patients with ACAS is largely based on outdated randomized-controlled trials that lack the integration of improved medical therapies and risk factor control. Furthermore, recent circulating and imaging biomarkers for stroke have never been included in a risk stratification model. The TAXINOMISIS Project aims to develop a new risk stratification model for cerebrovascular complications in patients with ACAS and this will be tested through a prospective observational multicentre clinical trial performed in six major European vascular surgery centres. METHODS AND ANALYSIS: The risk stratification model will compromise clinical, circulating, plaque and imaging biomarkers. The prospective multicentre observational study will include 300 patients with 50%-99% ACAS. The primary endpoint is the three-year incidence of cerebrovascular complications. Biomarkers will be retrieved from plasma samples, brain MRI, carotid MRA and duplex ultrasound. The TAXINOMISIS Project will serve as a platform for the development of new computer tools that assess plaque progression based on radiology images and a lab-on-chip with genetic variants that could predict medication response in individual patients. CONCLUSION: Results from the TAXINOMISIS study could potentially improve future risk stratification in patients with ACAS to assist personalized evidence-based treatment decision-making.
Kokoelmat
- TUNICRIS-julkaisut [17036]