Corrected whole blood biomarkers : the equation of Dill and Costill revisited
Matomäki, P., Kainulainen, H., & Kyröläinen, H. (2018). Corrected whole blood biomarkers : the equation of Dill and Costill revisited. Physiological Reports, 6(12), Article e13749. https://doi.org/10.14814/phy2.13749
Julkaistu sarjassa
Physiological ReportsPäivämäärä
2018Tekijänoikeudet
© 2018 The Authors
An exercise bout or a dehydration often causes a reduction in plasma volume,
which should be acknowledged when considering the change in biomarkers
before and after the plasma changing event. The classic equation from Dill
and Costill (1974, J. Appl. Physiol., 37, 247–248) for plasma volume shift is
usually utilized in such a case. Although this works well with plasma and
serum biomarkers, we argue in this note that this traditional approach gives
misleading results in the context of whole blood biomarkers, such as lactate,
white cells, and thrombocytes. In this study, we demonstrate that to calculate
the change in the total amount of circulating whole blood biomarker, one
should utilize a formula BMpost
BMpre
Hbpre
Hbpost
1:
Here Hb and BM are, respectively, the concentrations for the hemoglobin and
for the inspected whole blood biomarker before (pre) and after (post) the
plasma changing incident.
Julkaisija
Wiley Periodicals; American Physiological Society; Physiological SocietyISSN Hae Julkaisufoorumista
2051-817XAsiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/28135725
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