Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
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Computational approach to design of aptamers to the receptor binding domain of SARS-CoV-2
Artyushenko, P. V.; Mironov, V. A.; Morozov, D. I.; Shchugoreva, I. A.; Borbone, N.; Tomilin, F. N.; Kichkailo, A. S. (Krasnoyarsk State Medical University, 2021)The aim of the research. In this work, in silico selection of DNA-aptamers to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein was performed using molecular modeling methods. Material and methods. A ... -
Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13
Juvonen, Risto O.; Jokinen, Elmeri M.; Huuskonen, Juhani; Kärkkäinen, Olli; Raunio, Hannu; Pentikäinen, Olli T. (Informa Healthcare, 2021)1.CYP2A13 enzyme is expressed in human extrahepatic tissues, while CYP2A6 is a hepatic enzyme. Reactions catalyzed by CYP2A13activate tobacco-specificnitrosamines and some other toxic xenobioticsin lungs. 2.To compare ... -
Higher glucose availability augments the metabolic responses of the C2C12 myotubes to exercise-like electrical pulse stimulation
Lautaoja, Juulia H.; O'Connell, Thomas; Mäntyselkä, Sakari; Peräkylä, Juuli; Kainulainen, Heikki; Pekkala, Satu; Permi, Perttu; Hulmi, Juha J. (American Physiological Society, 2021)The application of exercise-like electrical pulse simulation (EL-EPS) has become a widely used exercise mimetic in vitro. EL-EPS produces similar physiological responses as in vivo exercise, while less is known about the ... -
How to preserve and handle fish liver samples to conserve RNA integrity
Vehniäinen, Eeva-Riikka; Ruusunen, Maiju; Vuorinen, Pekka J.; Keinänen, Marja; Oikari, Aimo; Kukkonen, Jussi (Springer, 2019)As transcriptomic studies are becoming more and more common, it is important to ensure that the RNA used in the analyses is of good quality. The RNA integrity may be compromised by storage temperature or freeze-thaw cycles, ... -
Substrate Selectivity of Coumarin Derivatives by Human CYP1 Enzymes : In Vitro Enzyme Kinetics and In Silico Modeling
Juvonen, Risto O.; Ahinko, Mira; Jokinen, Elmeri M.; Huuskonen, Juhani; Raunio, Hannu; Pentikäinen, Olli T. (American Chemical Society (ACS), 2021)Of the three enzymes in the human cytochrome P450 family 1, CYP1A2 is an important enzyme mediating metabolism of xenobiotics including drugs in the liver, while CYP1A1 and CYP1B1 are expressed in extrahepatic tissues. ...
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