Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018
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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2019-05-01
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Mcode
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Language
en
Pages
1-3
Series
EUROSURVEILLANCE, Volume 24, issue 19
Abstract
In December 2018, a ceftazidime-avibactam (CAZ-AVI)-resistant KPC-2-producing Klebsiella pneumoniae strain was isolated in Finland. CAZ-AVI resistance was observed 34 days after CAZ-AVI treatment in a trauma patient transferred from a hospital in Greece who had been colonised with blaKPC-2-producing K. pneumoniae ST39, and later developed a bloodstream infection. The CAZ-AVI-resistant strain contained a novel 15 amino acid insertion in the KPC-2 protein causing structural changes proximal to the KPC-2 active site.Description
Keywords
carbapenem, ceftazidime-avibactam, Klebsiella pneumoniae, resistance, whole-genome sequencing, KPC-2
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Citation
Räisänen, K, Koivula, I, Ilmavirta, H, Puranen, S, Kallonen, T, Lyytikäinen, O & Jalava, J 2019, ' Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018 ', EUROSURVEILLANCE, vol. 24, no. 19, pp. 1-3 . https://doi.org/10.2807/1560-7917.ES.2019.24.19.1900256