TY - JOUR
T1 - Tailored approaches in drug development and diagnostics: from molecular design to biological model systems
AU - Sahlgren, Cecilia
AU - Meinander, Annika
AU - Zhang, Hongbo
AU - Cheng, Fang
AU - Preis, Maren
AU - Xu, Chunlin
AU - Salminen, Tiina
AU - Toivola, Diana
AU - Abankwa, Daniel
AU - Rosling, Ari
AU - Sen Karaman, Didem
AU - Salo-Ahen, Outi
AU - Österbacka, Ronald
AU - Eriksson, John
AU - Willför, Stefan
AU - Petre, Ion
AU - Peltonen, Jouko
AU - Leino, Reko
AU - Johnson, Mark S
AU - Rosenholm, Jessica
AU - Sandler, Niklas
N1 - 3pk
fys.
tpk
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PY - 2017
Y1 - 2017
N2 - Approaches to increase the efficiency in developing drugs and diagnostics tools, including new drug delivery and diagnostic technologies, are needed for improved diagnosis and treatment of major diseases and health problems such as cancer, inflammatory diseases, chronic wounds, and antibiotic resistance. Development within several areas of research ranging from computational sciences, material sciences, bioengineering to biomedical sciences and bioimaging is needed to realize innovative drug development and diagnostic (DDD) approaches. Here, an overview of recent progresses within key areas that can provide customizable solutions to improve processes and the approaches taken within DDD is provided. Due to the broadness of the area, unfortunately all relevant aspects such as pharmacokinetics of bioactive molecules and delivery systems cannot be covered. Tailored approaches within (i) bioinformatics and computer-aided drug design, (ii) nanotechnology, (iii) novel materials and technologies for drug delivery and diagnostic systems, and (iv) disease models to predict safety and efficacy of medicines under development are focused on. Current developments and challenges ahead are discussed. The broad scope reflects the multidisciplinary nature of the field of DDD and aims to highlight the convergence of biological, pharmaceutical, and medical disciplines needed to meet the societal challenges of the 21st century.
AB - Approaches to increase the efficiency in developing drugs and diagnostics tools, including new drug delivery and diagnostic technologies, are needed for improved diagnosis and treatment of major diseases and health problems such as cancer, inflammatory diseases, chronic wounds, and antibiotic resistance. Development within several areas of research ranging from computational sciences, material sciences, bioengineering to biomedical sciences and bioimaging is needed to realize innovative drug development and diagnostic (DDD) approaches. Here, an overview of recent progresses within key areas that can provide customizable solutions to improve processes and the approaches taken within DDD is provided. Due to the broadness of the area, unfortunately all relevant aspects such as pharmacokinetics of bioactive molecules and delivery systems cannot be covered. Tailored approaches within (i) bioinformatics and computer-aided drug design, (ii) nanotechnology, (iii) novel materials and technologies for drug delivery and diagnostic systems, and (iv) disease models to predict safety and efficacy of medicines under development are focused on. Current developments and challenges ahead are discussed. The broad scope reflects the multidisciplinary nature of the field of DDD and aims to highlight the convergence of biological, pharmaceutical, and medical disciplines needed to meet the societal challenges of the 21st century.
KW - drug-delivery systems
KW - Nanoparticles
KW - Diagnostics
KW - Personalized medicine
KW - Chemistry and Materials Science
KW - bioinformatics
KW - Disease Models, Animal
KW - drug-delivery systems
KW - Nanoparticles
KW - Diagnostics
KW - Personalized medicine
KW - Chemistry and Materials Science
KW - bioinformatics
KW - Disease Models, Animal
KW - drug-delivery systems
KW - Nanoparticles
KW - Diagnostics
KW - Personalized medicine
KW - Chemistry and Materials Science
KW - bioinformatics
KW - Disease Models, Animal
U2 - 10.1002/adhm.201700258
DO - 10.1002/adhm.201700258
M3 - Översiktsartikel
SN - 2192-2640
SP - 1
EP - 34
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
ER -