Abstract
Conducting hydrogels provide great potential for creating designer shape-morphing architectures for biomedical applications owing to their unique solid-liquid interface and ease of processability. Here, a novel nanofibrous hydrogel with significant enzyme-like activity that can be used as ink to print flexible electrochemical devices is developed. The nanofibrous hydrogel is self-assembled from guanosine (G) and KB(OH)(4) with simultaneous incorporation of hemin into the G-quartet scaffold, giving rise to significant enzyme-like activity. The rapid switching between the sol and gel states responsive to shear stress enables free-form fabrication of different patterns. Furthermore, the replication of the G-quartet wires into a conductive matrix by in situ catalytic deposition of polyaniline on nanofibers is demonstrated, which can be directly printed into a flexible electrochemical electrode. By loading glucose oxidase into this novel hydrogel, a flexible glucose biosensor is developed. This study sheds new light on developing artificial enzymes with new functionalities and on fabrication of flexible bioelectronics.
Original language | Undefined/Unknown |
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Pages (from-to) | – |
Number of pages | 8 |
Journal | Advanced Materials |
Volume | 30 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2018 |
MoE publication type | A1 Journal article-refereed |
Keywords
- enzyme mimicking
- flexible electrochemical sensors
- guanosine
- low-molecular-weight hydrogels
- self-assembly