Transient ordered domains in single-component phospholipid bilayers
Murtola, T.; Rog, T.; Falck, E.; Karttunen, M.; Vattulainen, I. (2006)
Murtola, T.
Rog, T.
Falck, E.
Karttunen, M.
Vattulainen, I.
2006
Julkaisun pysyvä osoite on
https://urn.fi/URN:NBN:fi:tty-201104155817
https://urn.fi/URN:NBN:fi:tty-201104155817
Kuvaus
Peer reviewed
Tiivistelmä
We report evidence of dense, ordered nanodomains in single-component fluid lipid bilayers. Our atomic-scale molecular dynamics simulations suggest that the area available to a lipid acyl chain exhibits large fluctuations, resulting in denser and sparser domains. The sizes of the dense domains can be up to ∼10 nm, and their lifetimes are of the order of ∼10 ns. In addition, our simulations suggest that domains of lipids with highly ordered acyl chains form predominantly within the dense regions, their sizes ranging from a few chains up to a few nanometers, and with lifetimes between ∼10 ps–10 ns. These observations shed light on the origin of experimentally observed fluctuations, as well as on the mechanisms of phase transitions in lipid membranes.
Kokoelmat
- TUNICRIS-julkaisut [16740]